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Manganese in PDB 1lev: Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor

Enzymatic activity of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor

All present enzymatic activity of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor:
3.1.3.11;

Protein crystallography data

The structure of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor, PDB code: 1lev was solved by S.W.Wright, A.A.Carlo, D.E.Danley, D.L.Hageman, G.A.Karam, M.N.Mansour, L.D.Mcclure, J.Pandit, G.K.Schulte, J.L.Treadway, I.-K.Wang, P.H.Bauer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.26 / 2.15
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 118.870, 73.446, 78.025, 90.00, 106.30, 90.00
R / Rfree (%) 19.3 / 25.5

Other elements in 1lev:

The structure of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor (pdb code 1lev). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor, PDB code: 1lev:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 1lev

Go back to Manganese Binding Sites List in 1lev
Manganese binding site 1 out of 4 in the Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn340

b:38.0
occ:1.00
OE2 A:GLU280 2.2 37.7 1.0
OD2 A:ASP118 2.4 31.9 1.0
OE1 A:GLU97 2.5 37.8 1.0
O A:HOH363 2.8 30.7 1.0
CG A:ASP118 3.1 24.9 1.0
MN A:MN341 3.3 47.4 1.0
CD A:GLU280 3.3 29.3 1.0
OD1 A:ASP118 3.4 31.1 1.0
CD A:GLU97 3.5 32.8 1.0
OD1 A:ASP121 3.5 26.7 1.0
OE2 A:GLU97 3.8 37.8 1.0
O1 A:F6P338 3.9 32.0 1.0
CG A:GLU280 4.0 25.7 1.0
C1 A:F6P338 4.1 31.7 1.0
CA A:ASP121 4.2 43.7 1.0
CB A:ASP121 4.2 41.9 1.0
OE1 A:GLU280 4.3 23.4 1.0
CB A:ASP118 4.3 17.6 1.0
CG A:ASP121 4.4 43.5 1.0
CG A:GLU97 4.8 28.8 1.0
N A:GLY122 4.9 57.4 1.0

Manganese binding site 2 out of 4 in 1lev

Go back to Manganese Binding Sites List in 1lev
Manganese binding site 2 out of 4 in the Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn341

b:47.4
occ:1.00
OD1 A:ASP118 2.4 31.1 1.0
OE2 A:GLU97 2.6 37.8 1.0
O A:LEU120 2.9 30.7 1.0
O A:HOH368 2.9 44.1 1.0
O A:HOH363 3.1 30.7 1.0
CD A:GLU97 3.2 32.8 1.0
CG A:ASP118 3.2 24.9 1.0
MN A:MN340 3.3 38.0 1.0
OD2 A:ASP118 3.3 31.9 1.0
OE1 A:GLU97 3.3 37.8 1.0
C A:LEU120 3.5 32.4 1.0
OE2 A:GLU98 3.8 37.8 1.0
N A:ASP121 4.0 39.6 1.0
CA A:ASP121 4.0 43.7 1.0
N A:LEU120 4.2 25.0 1.0
CG A:GLU97 4.4 28.8 1.0
CA A:LEU120 4.4 28.3 1.0
CB A:GLU97 4.5 20.4 1.0
CB A:ASP118 4.7 17.6 1.0
CD A:PRO119 4.8 25.4 1.0
CD A:GLU98 4.8 37.4 1.0
CB A:ASP121 4.9 41.9 1.0
N A:PRO119 5.0 24.4 1.0
CA A:ASP118 5.0 20.0 1.0

Manganese binding site 3 out of 4 in 1lev

Go back to Manganese Binding Sites List in 1lev
Manganese binding site 3 out of 4 in the Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn342

b:34.9
occ:1.00
OD2 F:ASP118 2.2 27.1 1.0
OE2 F:GLU280 2.3 38.0 1.0
OE1 F:GLU97 2.4 29.8 1.0
OD1 F:ASP121 2.5 26.7 1.0
CG F:ASP118 3.2 20.3 1.0
CD F:GLU280 3.2 26.3 1.0
MN F:MN343 3.4 52.9 1.0
CD F:GLU97 3.5 32.5 1.0
CG F:ASP121 3.5 42.8 1.0
O1 F:F6P338 3.6 37.9 1.0
OD1 F:ASP118 3.7 24.4 1.0
CG F:GLU280 3.8 18.3 1.0
CB F:ASP121 3.8 39.1 1.0
OE2 F:GLU97 3.9 40.2 1.0
OE1 F:GLU280 4.1 20.8 1.0
CA F:ASP121 4.2 43.5 1.0
C1 F:F6P338 4.3 33.0 1.0
CB F:ASP118 4.4 19.6 1.0
OD2 F:ASP121 4.6 38.1 1.0
CG F:GLU97 4.7 24.2 1.0
O F:HOH383 4.9 34.9 1.0
N F:GLY122 4.9 57.6 1.0

Manganese binding site 4 out of 4 in 1lev

Go back to Manganese Binding Sites List in 1lev
Manganese binding site 4 out of 4 in the Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Porcine Kidney Fructose-1,6-Bisphosphatase Complexed with An Amp-Site Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn343

b:52.9
occ:1.00
OD1 F:ASP118 2.3 24.4 1.0
OE2 F:GLU97 2.4 40.2 1.0
O F:LEU120 2.8 31.9 1.0
CD F:GLU97 3.1 32.5 1.0
CG F:ASP118 3.1 20.3 1.0
OE1 F:GLU97 3.2 29.8 1.0
OD2 F:ASP118 3.2 27.1 1.0
MN F:MN342 3.4 34.9 1.0
C F:LEU120 3.4 32.3 1.0
OE2 F:GLU98 3.5 38.5 1.0
CA F:ASP121 3.9 43.5 1.0
N F:ASP121 4.0 39.6 1.0
N F:LEU120 4.2 22.1 1.0
CA F:LEU120 4.4 26.6 1.0
CG F:GLU97 4.4 24.2 1.0
CB F:GLU97 4.4 20.4 1.0
CB F:ASP118 4.6 19.6 1.0
CB F:ASP121 4.6 39.1 1.0
CD F:GLU98 4.6 38.8 1.0
OD1 F:ASP121 4.8 26.7 1.0
CD F:PRO119 4.8 21.7 1.0
CA F:ASP118 5.0 19.3 1.0
N F:PRO119 5.0 21.8 1.0

Reference:

S.W.Wright, A.A.Carlo, D.E.Danley, D.L.Hageman, G.A.Karam, M.N.Mansour, L.D.Mcclure, J.Pandit, G.K.Schulte, J.L.Treadway, I.-K.Wang, P.H.Bauer. 3-(2-Carboxyethyl)-4,6-Dichloro-1H-Indole-2-Carboxylic Acid: An Allosteric Inhibitor of Fructose-1,6-Bisphosphatase at the Amp Site. Bioorg.Med.Chem.Lett. V. 13 2055 2003.
ISSN: ISSN 0960-894X
PubMed: 12781194
DOI: 10.1016/S0960-894X(03)00310-X
Page generated: Sat Oct 5 11:27:36 2024

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