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Manganese in PDB 1cw1: Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+

Enzymatic activity of Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+

All present enzymatic activity of Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+:
1.1.1.42;

Protein crystallography data

The structure of Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+, PDB code: 1cw1 was solved by R.Stroud, J.Finer-Moore, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 5.53 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 102.800, 102.800, 150.100, 90.00, 90.00, 90.00
R / Rfree (%) 19 / 23.3

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+ (pdb code 1cw1). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+, PDB code: 1cw1:

Manganese binding site 1 out of 1 in 1cw1

Go back to Manganese Binding Sites List in 1cw1
Manganese binding site 1 out of 1 in the Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Isocitrate Dehydrogenase Mutant K230M Bound to Isocitrate and MN2+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn418

b:52.9
occ:0.50
O7 A:ICT417 2.2 42.2 0.5
O1 A:ICT417 2.5 41.3 0.5
C1 A:ICT417 2.8 38.3 0.5
OD1 A:ASP307 3.0 16.2 1.0
C2 A:ICT417 3.1 40.8 0.5
O6 A:ICT417 3.1 45.8 0.5
O A:HOH490 3.1 38.8 1.0
O A:HOH751 3.2 37.4 1.0
OD2 A:ASP311 3.5 14.7 1.0
O A:HOH482 3.5 27.6 1.0
O2 A:ICT417 3.6 35.1 0.5
O A:HOH750 3.7 55.2 1.0
C6 A:ICT417 3.9 44.0 0.5
C3 A:ICT417 4.0 42.5 0.5
CG A:ASP307 4.1 16.4 1.0
OD1 A:ASP311 4.2 16.7 1.0
O A:HOH545 4.2 55.1 1.0
CG A:ASP311 4.2 13.1 1.0
OD2 A:ASP307 4.4 19.6 1.0
C4 A:ICT417 4.8 42.4 0.5

Reference:

D.B.Cherbavaz, M.E.Lee, R.M.Stroud, D.E.Koshland Jr.. Active Site Water Molecules Revealed in the 2.1 A Resolution Structure of A Site-Directed Mutant of Isocitrate Dehydrogenase. J.Mol.Biol. V. 295 377 2000.
ISSN: ISSN 0022-2836
PubMed: 10623532
DOI: 10.1006/JMBI.1999.3195
Page generated: Sat Oct 5 10:02:31 2024

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