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Manganese in PDB 1ad4: Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus

Enzymatic activity of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus

All present enzymatic activity of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus:
2.5.1.15;

Protein crystallography data

The structure of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus, PDB code: 1ad4 was solved by C.Oefner, D.Kostrewa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 13.00 / 2.40
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 65.748, 42.142, 99.040, 90.00, 106.06, 90.00
R / Rfree (%) 17.6 / n/a

Other elements in 1ad4:

The structure of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus also contains other interesting chemical elements:

Potassium (K) 2 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus (pdb code 1ad4). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus, PDB code: 1ad4:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in 1ad4

Go back to Manganese Binding Sites List in 1ad4
Manganese binding site 1 out of 3 in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn268

b:42.3
occ:1.00
O B:HOH423 2.1 65.2 1.0
O A:HOH413 2.2 43.9 1.0
NE2 A:HIS264 2.4 36.7 1.0
O B:HOH422 2.4 67.2 1.0
CD2 A:HIS264 3.0 28.7 1.0
CE1 A:HIS264 3.5 38.6 1.0
OD2 B:ASP187 4.0 26.8 1.0
CG A:HIS264 4.2 39.1 1.0
OD1 B:ASP187 4.3 22.7 1.0
ND1 A:HIS264 4.4 40.2 1.0
OE2 B:GLU188 4.5 17.4 1.0
CG B:ASP187 4.5 23.2 1.0

Manganese binding site 2 out of 3 in 1ad4

Go back to Manganese Binding Sites List in 1ad4
Manganese binding site 2 out of 3 in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn269

b:37.7
occ:1.00
O6P A:HH2271 2.0 16.8 1.0
O A:HOH407 2.3 34.6 1.0
O A:HOH362 2.3 29.3 1.0
OD1 A:ASN11 2.4 34.0 1.0
P2 A:HH2271 3.5 18.1 1.0
O2P A:HH2271 3.6 14.8 1.0
CG A:ASN11 3.6 28.4 1.0
NH2 A:ARG239 4.1 9.9 1.0
O3P A:HH2271 4.1 14.1 1.0
O A:HOH406 4.1 23.5 1.0
O A:VAL49 4.2 29.8 1.0
O A:HOH326 4.2 18.1 1.0
O4 A:HH2271 4.2 11.7 1.0
P1 A:HH2271 4.2 15.1 1.0
O5P A:HH2271 4.3 1.1 1.0
ND2 A:ASN11 4.3 26.4 1.0
C3 A:HH2271 4.4 14.6 1.0
O4P A:HH2271 4.5 11.1 1.0
OD2 A:ASP84 4.7 22.0 1.0
CB A:ASN11 4.8 21.2 1.0
O A:GLY47 4.8 23.4 1.0
C A:GLY47 4.9 19.6 1.0

Manganese binding site 3 out of 3 in 1ad4

Go back to Manganese Binding Sites List in 1ad4
Manganese binding site 3 out of 3 in the Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Dihydropteroate Synthetase Complexed with Oh-CH2-Pterin- Pyrophosphate From Staphylococcus Aureus within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn1

b:27.9
occ:1.00
O A:HOH372 2.1 34.5 1.0
NE2 B:HIS264 2.2 20.4 1.0
O A:HOH357 2.3 16.0 1.0
O B:HOH416 2.3 29.1 1.0
O B:HOH417 2.5 37.8 1.0
CD2 B:HIS264 3.0 11.2 1.0
CE1 B:HIS264 3.3 15.3 1.0
OD2 A:ASP187 4.1 19.7 1.0
CG B:HIS264 4.2 13.6 1.0
OD1 A:ASP187 4.2 21.9 1.0
OE2 A:GLU188 4.2 6.3 1.0
ND1 B:HIS264 4.2 11.5 1.0
CG A:ASP187 4.6 16.3 1.0
O A:ALA184 4.8 10.3 1.0
O A:HOH288 4.9 12.9 1.0

Reference:

I.C.Hampele, A.D'arcy, G.E.Dale, D.Kostrewa, J.Nielsen, C.Oefner, M.G.Page, H.J.Schonfeld, D.Stuber, R.L.Then. Structure and Function of the Dihydropteroate Synthase From Staphylococcus Aureus. J.Mol.Biol. V. 268 21 1997.
ISSN: ISSN 0022-2836
PubMed: 9149138
DOI: 10.1006/JMBI.1997.0944
Page generated: Tue Dec 15 03:46:05 2020

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