Manganese in PDB 9ere: SLFN11 Dimer Bound to Trna-Leu-Taa

The structure of SLFN11 Dimer Bound to Trna-Leu-Taa also contains other interesting chemical elements:

Zinc	(Zn)	2 atoms
Magnesium	(Mg)	4 atoms

The binding sites of Manganese atom in the SLFN11 Dimer Bound to Trna-Leu-Taa (pdb code 9ere). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the SLFN11 Dimer Bound to Trna-Leu-Taa, PDB code: 9ere:
Jump to Manganese binding site number: 1; 2; 3;

Manganese binding site 1 out of 3 in the SLFN11 Dimer Bound to Trna-Leu-Taa


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of SLFN11 Dimer Bound to Trna-Leu-Taa within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1002 b:42.9 occ:1.00 OE2 A:GLU214 1.9 33.6 1.0 OD2 A:ASP252 1.9 41.6 1.0 OE2 A:GLU209 2.1 42.0 1.0 O A:PHE215 2.3 35.3 1.0 CD A:GLU214 3.0 28.0 1.0 CD A:GLU209 3.2 33.9 1.0 OP1 T:U65 3.2 45.5 1.0 CG A:ASP252 3.2 41.0 1.0 C A:PHE215 3.4 33.3 1.0 CE A:LYS216 3.5 39.9 1.0 OE1 A:GLU209 3.6 40.9 1.0 N A:PHE215 3.7 30.2 1.0 OE1 A:GLU214 3.8 32.8 1.0 CG A:GLU214 3.9 22.1 1.0 OD1 A:ASP252 4.0 41.8 1.0 CA A:PHE215 4.0 28.9 1.0 CB A:ASP252 4.1 41.4 1.0 OP2 T:C66 4.1 41.3 1.0 NZ A:LYS216 4.2 40.0 1.0 N A:LYS216 4.4 32.4 1.0 CB A:PHE215 4.4 31.2 1.0 CG A:GLU209 4.4 28.0 1.0 P T:U65 4.5 45.5 1.0 C A:GLU214 4.7 28.8 1.0 C5' T:U65 4.7 37.1 1.0 O5' T:U65 4.7 40.4 1.0 CD A:LYS216 4.7 32.4 1.0 CA A:LYS216 4.8 28.1 1.0 CA A:ASP252 4.9 43.7 1.0 CG A:LYS216 4.9 34.1 1.0 CA A:GLU214 4.9 24.7 1.0

Manganese binding site 2 out of 3 in the SLFN11 Dimer Bound to Trna-Leu-Taa


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of SLFN11 Dimer Bound to Trna-Leu-Taa within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1002 b:39.2 occ:1.00 OE2 B:GLU214 2.1 42.5 1.0 OP1 U:C77 2.1 71.2 1.0 OD2 B:ASP252 2.1 59.1 1.0 OE2 B:GLU209 2.2 38.9 1.0 O B:PHE215 2.3 41.4 1.0 CD B:GLU209 3.1 32.5 1.0 CD B:GLU214 3.2 36.9 1.0 OE1 B:GLU209 3.3 33.5 1.0 MN B:MN1003 3.3 69.9 1.0 CG B:ASP252 3.3 60.9 1.0 C B:PHE215 3.4 36.9 1.0 P U:C77 3.5 78.9 1.0 N B:PHE215 3.8 35.6 1.0 CE B:LYS216 3.9 45.1 1.0 CG B:GLU214 4.0 27.8 1.0 CA B:PHE215 4.1 32.9 1.0 OE1 B:GLU214 4.1 38.3 1.0 CB B:ASP252 4.2 61.2 1.0 OD1 B:ASP252 4.2 59.3 1.0 OP2 U:C77 4.2 70.3 1.0 CD B:LYS216 4.4 46.0 1.0 CB B:PHE215 4.4 39.1 1.0 CG B:GLU209 4.5 30.0 1.0 N B:LYS216 4.5 45.0 1.0 O5' U:C77 4.5 75.5 1.0 C5' U:C77 4.5 72.5 1.0 CG B:LYS216 4.7 41.3 1.0 CA B:LYS216 4.8 43.2 1.0 NZ B:LYS216 4.8 45.7 1.0 C B:GLU214 4.8 32.7 1.0

Manganese binding site 3 out of 3 in the SLFN11 Dimer Bound to Trna-Leu-Taa


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of SLFN11 Dimer Bound to Trna-Leu-Taa within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1003 b:69.9 occ:1.00 OE2 B:GLU214 2.4 42.5 1.0 OE1 B:GLU209 2.6 33.5 1.0 OE1 B:GLU214 2.6 38.3 1.0 CD B:GLU214 2.9 36.9 1.0 O B:THR138 2.9 28.4 1.0 MN B:MN1002 3.3 39.2 1.0 CD B:GLU209 3.4 32.5 1.0 OE2 B:GLU209 3.7 38.9 1.0 C B:THR138 4.2 23.5 1.0 OP1 U:C77 4.2 71.2 1.0 NH1 B:ARG135 4.3 27.9 1.0 OD2 B:ASP252 4.4 59.1 1.0 CG B:GLU214 4.4 27.8 1.0 NH2 B:ARG135 4.5 23.9 1.0 OP2 U:C77 4.5 70.3 1.0 CG B:GLU209 4.7 30.0 1.0 CB B:THR138 4.8 26.6 1.0 OH B:TYR234 4.8 40.7 1.0 CB B:GLU209 4.8 28.2 1.0 CZ B:ARG135 4.8 20.9 1.0 P U:C77 4.9 78.9 1.0 CA B:THR138 4.9 17.9 1.0

M.Kugler, F.J.Metzner, K.P.Hopfner, K.Lammens. Phosphorylation-Mediated Conformational Change Regulates Human SLFN11 Nat Commun 2024.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-024-54833-7